Responsibilities Model Development: Build and validate predictive models across key ADMET and PK/PD endpoints (clearance, permeability, solubility, metabolic stability, DDI risk, transporter liabilities, exposure–toxicity relationships, and PK/PD) with mechanistic grounding and designed for partner use. Translational Modeling: Develop translational modeling approaches (PBPK, IVIVE, PK/PD simulation) to bridge preclinical and clinical settings and generate actionable predictions for biotech partners across diverse programs and modalities. Distribution Modeling: Develop mechanistic and data‑driven models for tissue distribution, volume of distribution, plasma protein binding, and blood‑brain barrier penetration; calibrate across relevant species for human translatability. Partner Enablement & Usability: Translate ADMET/PK/PD science into practical, interpretable model outputs and workflows; create documentation, decision frameworks, and companion guidance for varying partner quantitative expertise. Data Strategy & Validation: Define data requirements and validation approaches; identify training data gaps and collaborate to address them via targeted experimental or modeling initiatives. AI & Tool Integration: Use AI/agentic tools to automate data pipelines, improve model interpretability, and streamline output delivery across TuneLab’s federated network. Mentorship: Coach junior scientists and grow TuneLab’s ADMET and PK/PD modeling capabilities. Qualifications Education: PhD in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Clinical Pharmacology, Drug Metabolism, Toxicology, or a related STEM discipline. Experience: 7+ years in ADME/PKPD, Pharmacometrics, Translational Medicine, or a closely related field. Preferred Skills/Experience Hands‑on experience with modeling platforms such as SimCYP, GastroPlus, PK‑Sim, NONMEM, Monolix, R, Matlab. Knowledge of medicinal chemistry and/or toxicology principles. Experience with small molecule discovery (Beyond‑Rule‑of‑Five and pan‑modality chemotypes). Strong communication skills to make complex quantitative science accessible. Track record of scientific contributions to pharmacokinetics, pharmacodynamics, ADMET, or pharmaceutical sciences. Benefits Anticipated pay range: $177,000–$308,000. Company bonus for eligible full‑time employees (depending on company and individual performance). Eligible benefits may include 401(k), pension, vacation, medical/dental/vision/prescription coverage, flexible benefits (e.g., healthcare/dependent day care FSAs), life insurance/death benefits, time off/leave benefits, and well‑being benefits (e.g., employee assistance, fitness, clubs/activities). Application instructions: If you require accommodation to submit a resume, complete the workplace accommodation request form: #J-18808-Ljbffr